TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection.

@article{Loures2009TLR2IA,
  title={TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection.},
  author={Fl{\'a}vio Vieira Loures and Adriana Pina and Ma{\'i}ra Felonato and Vera L G Calich},
  journal={Journal of immunology},
  year={2009},
  volume={183 2},
  pages={1279-90}
}
To study the role of TLR2 in a experimental model of chronic pulmonary infection, TLR2-deficient and wild-type mice were intratracheally infected with Paracoccidioides brasiliensis, a primary fungal pathogen. Compared with control, TLR2(-/-) mice developed a less severe pulmonary infection and decreased NO synthesis. Equivalent results were detected with in vitro-infected macrophages. Unexpectedly, despite the differences in fungal loads both mouse strains showed equivalent survival times and… CONTINUE READING

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