TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes.

@article{Philippe2012TLR2EI,
  title={TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes.},
  author={Lucas Philippe and Ghada Alsaleh and Guillaume Suffert and Alain Meyer and Philippe Georgel and Jean Sibilia and Dominique Wachsmann and S{\'e}bastien Pfeffer},
  journal={Journal of immunology},
  year={2012},
  volume={188 1},
  pages={454-61}
}
Resident cells, such as fibroblast-like synoviocytes (FLS), play a crucial role in rheumatoid arthritis (RA). They are implicated in the inflammatory response and play a key role in osteoarticular destruction. Moreover, RA FLS spread RA to unaffected joints. Pathogen-associated molecular patterns and damage-associated molecular patterns have been found to activate RA FLS by interacting with pattern recognition receptors, such as TLR. RA FLS express a large number of TLR, and TLR2 was… CONTINUE READING
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