TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal.

@article{Mercier2009TLR2EO,
  title={TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal.},
  author={Blandine C. Mercier and Anne Cottalorda and Charles-Antoine Coupet and Jacqueline Marvel and Nathalie Bonnefoy-B{\'e}rard},
  journal={Journal of immunology},
  year={2009},
  volume={182 4},
  pages={1860-7}
}
TLR are involved in the detection of microbial infection as well as endogenous ligands that signal tissue and cell damage in mammals. This recognition plays an essential role in innate immune response and the initiation of adaptive immune response. We have previously shown that murine CD8 T cells express TLR2, and that costimulation of Ag-activated CD8 T cells with TLR2 ligands enhances their proliferation, survival, and effector functions. We also demonstrated that TLR2 engagement on CD8 T… CONTINUE READING