TLR2 but not TLR4 signalling is critically involved in the inhibition of IFN-gamma-induced killing of mycobacteria by murine macrophages.

@article{ArkoMensah2007TLR2BN,
  title={TLR2 but not TLR4 signalling is critically involved in the inhibition of IFN-gamma-induced killing of mycobacteria by murine macrophages.},
  author={John Arko-Mensah and Esther Juli{\'a}n and Mahavir Singh and Carmen Fern{\'a}ndez},
  journal={Scandinavian journal of immunology},
  year={2007},
  volume={65 2},
  pages={148-57}
}
Gamma-interferon (IFN-gamma) plays a determinant role in activating macrophages that are critical to control Mycobacterium tuberculosis infection. However, M. tuberculosis can escape killing by attenuating the response of macrophages to IFN-gamma by blocking the transcription of a subset of IFN-gamma inducible genes. This inhibition occurs after signalling through Toll-like receptor 2 (TLR2). While most studies have investigated the inhibition of IFN-gamma responsive genes after TLR2 signalling… CONTINUE READING
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