TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide

  title={TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide},
  author={Joan F. Burgue{\~n}o and Albert Barba and Elena Eyre and Carolina B Romero and Michel Neunlist and Ester Corbacho Fern{\'a}ndez},
  booktitle={Journal of Neuroinflammation},
Accumulating evidence suggest that the enteric nervous system (ENS) plays important roles in gastrointestinal inflammatory responses, which could be in part mediated by Toll-like receptor (TLR) activation. The aim of this study was to characterise the expression and functionality of TLR2/4/9 in the ENS. TLR2/4/9 expression was assessed in the plexuses of adult rats and embryonic ENS cultures by immunofluorescence and quantitative PCR. Following stimulation with TLR2/4/9 ligands or their… CONTINUE READING
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