TLR2 and TLR4 in autoimmune diseases: a comprehensive review.

  title={TLR2 and TLR4 in autoimmune diseases: a comprehensive review.},
  author={Yu Liu and Heng Yin and Mingming Zhao and Qian-jin Lu},
  journal={Clinical reviews in allergy & immunology},
  volume={47 2},
Autoimmune diseases are immune disorders characterized by T cell hyperactivity and B cell overstimulation leading to overproduction of autoantibodies. Although the pathogenesis of various autoimmune diseases remains to be elucidated, environmental factors have been thought to contribute to the initiation and maintenance of auto-respond inflammation. Toll-like receptors (TLRs) are pattern recognition receptors belonging to innate immunity that recognize and defend invading microorganisms… CONTINUE READING
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