TLR2 and TLR4 Play Opposite Role in Autophagy associated with Cisplatin-Induced Acute Kidney Injury.

@article{AndradeSilva2018TLR2AT,
  title={TLR2 and TLR4 Play Opposite Role in Autophagy associated with Cisplatin-Induced Acute Kidney Injury.},
  author={Magaiver Andrade-Silva and Marcos Ant{\^o}nio Cenedeze and Luiz Augusto Perandini and Raphael Jos{\'e} Ferreira Felizardo and Ingrid Kazue Mizuno Watanabe and Juan Sebastian Henao Agudelo and {\^A}ngela Castoldi and Giselle Martins Gonçalves and Clarice Silvia Taemi Origassa and Patr{\'i}cia Semedo and Meire Ioshie Hiyane and Orestes Foresto Neto and Denise Maria Avancini Costa Malheiros and Marlene Ant{\^o}nia dos Reis and Clarice Kazue Fujihara and Roberto Zatz and {\'A}lvaro Pacheco-Silva and Niels Olsen Saraiva C{\^a}mara and Danilo C{\^a}ndido de Almeida},
  journal={Clinical science},
  year={2018}
}
Acute kidney injury (AKI) is considered an inflammatory disease in which Toll-like receptors (TLRs) signaling pathways play an important role. The activation of TLRs results in production of several inflammatory cytokines leading to further renal damage. In contrast, TLRs are key players on autophagy induction, which is associated with a protective function… CONTINUE READING