TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy.

@article{Tsai2010TLR2AE,
  title={TLR2 agonists enhance CD8+Foxp3+ regulatory T cells and suppress Th2 immune responses during allergen immunotherapy.},
  author={Yi-Giien Tsai and Kuender D. Yang and D Niu and Jien-Wen Chien and C. -T. Lin},
  journal={Journal of immunology},
  year={2010},
  volume={184 12},
  pages={7229-37}
}
Pam3CSK4, a synthetic TLR2 ligand, has been shown to expand CD4+ regulatory T cells (Treg cells). Less is known about the function of CD8+ Treg cells than about the function of CD4+ Treg cells generated during allergen-specific immunotherapy (IT). This study investigated whether Dermatophagoides pteronyssinus-specific IT could expand the CD8+CD25+Foxp3… CONTINUE READING