TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.

Abstract

TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand specificity of TLR2 heterodimers has been studied extensively, using specific bacterial and… (More)
DOI: 10.1189/jlb.0113003

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