TLR2/TLR4-dependent exaggerated cytokine production in hyperimmunoglobulinaemia D and periodic fever syndrome.

Abstract

OBJECTIVE The autoinflammatory hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS) is characterized by recurrent episodes of fever and inflammation. As part of the mevalonate kinase deficiency spectrum, it is caused by MVK mutations, resulting in decreased mevalonate kinase activity in the isoprenoid pathway. Although IL-1β is considered a major… (More)
DOI: 10.1093/rheumatology/keu341

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Cite this paper

@article{Stoffels2015TLR2TLR4dependentEC, title={TLR2/TLR4-dependent exaggerated cytokine production in hyperimmunoglobulinaemia D and periodic fever syndrome.}, author={Monique Stoffels and Johanna van der Ven - Jongekrijg and Thijs Remijn and N F M Kok and Jos W M van der Meer and Anna Katharina Simon}, journal={Rheumatology}, year={2015}, volume={54 2}, pages={363-8} }