TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

@article{Nackiewicz2014TLR26AT,
  title={TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6},
  author={Dominika Nackiewicz and Meixia Dan and Wei He and Rosa Kim and Anisa Salmi and Sabine R{\"u}tti and Clara Y. Westwell-Roper and Amanda P Cunningham and Madeleine Speck and Carole Schuster-Klein and B{\'e}atrice Guardiola and Kathrin Maedler and Jan Adam Ehses},
  journal={Diabetologia},
  year={2014},
  volume={57},
  pages={1645-1654}
}
Inflammation contributes to pancreatic beta cell dysfunction in type 2 diabetes. Toll-like receptor (TLR)-2 and -4 ligands are increased systemically in recently diagnosed type 2 diabetes patients, and TLR2- and TLR4-deficient mice are protected from the metabolic consequences of a high-fat diet. Here we investigated the role of macrophages in TLR2/6- and TLR4-mediated effects on islet inflammation and beta cell function. Genetic and pharmacological approaches were used to determine the effects… CONTINUE READING