TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators

@inproceedings{Zoccal2014TLR2TA,
  title={TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators},
  author={Karina Furlani Zoccal and Claudia da Silva Bitencourt and Francisco Wanderley Garcia de Paula-Silva and Carlos Art{\'e}rio Sorgi and Karla de Castro Figueiredo Bordon and Eliane C Arantes and L{\'u}cia Helena Faccioli},
  booktitle={PloS one},
  year={2014}
}
Scorpion sting-induced human envenomation provokes an intense inflammatory reaction. However, the mechanisms behind the recognition of scorpion venom and the induction of mediator release in mammalian cells are unknown. We demonstrated that TLR2, TLR4 and CD14 receptors sense Tityus serrulatus venom (TsV) and its major component, toxin 1 (Ts1), to mediate cytokine and lipid mediator production. Additionally, we demonstrated that TsV induces TLR2- and TLR4/MyD88-dependent NF-κB activation and… CONTINUE READING
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Time course of acute-phase response induced by Tityus serrulatus venom and TsTX-I in mice

  • AC Pessini, AM de Souza, LH Faccioli, ZM Gregorio, EC Arantes
  • Int Immunopharmacol
  • 2003
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