TLR11 or TLR12 silencing reduces Leishmania major infection.

Abstract

Toll-like receptors (TLRs) recognize the pathogen-associated molecular patterns (PAMPs) and induce host-protective immune response. The role of the profilin-recognizing TLR11/TLR12 in Leishmania infection is unknown. Herein, we report that TLR11/ TLR12 expression increases in virulent L. major-infected macrophages but is prevented by miltefosine, an anti… (More)
DOI: 10.1016/j.cyto.2017.10.005

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