TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.

@article{Kesh2005TLR1AT,
  title={TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.},
  author={Sandra Kesh and Nana Yaa T Mensah and Paolo Peterlongo and Dana Jaffe and Katharine I. Hsu and Marcel R M van den Brink and Richard O'reilly and Eric G. Pamer and Jaya M. Satagopan and Genovefa Anna Papanicolaou},
  journal={Annals of the New York Academy of Sciences},
  year={2005},
  volume={1062},
  pages={95-103}
}
Toll-like receptors (TLRs) transmit signals in response to Aspergillus fumigatus conidia and hyphae. In this preliminary study, we examined the association between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell transplant recipients consisting of 22 patients with IA and 105 unaffected control subjects. The following SNPs and their pairwise interactions were considered in the model… CONTINUE READING
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