TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis

  title={TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis},
  author={Shiyan Yu and Yingchao Nie and Byron C. Knowles and Ryotaro Sakamori and Ewa Stypulkowski and Chirag Santosh Patel and Soumyashree Das and V{\'e}ronique Douard and Ronaldo P. Ferraris and Edward M. Bonder and James R Goldenring and Yicktung Tony Ip and Nan Papili Gao},
  booktitle={The EMBO journal},
Compartmentalization of Toll-like receptors (TLRs) in intestinal epithelial cells (IECs) regulates distinct immune responses to microbes; however, the specific cellular machinery that controls this mechanism has not been fully identified. Here we provide genetic evidences that the recycling endosomal compartment in enterocytes maintains a homeostatic TLR9 intracellular distribution, supporting mucosal tolerance to normal microbiota. Genetic ablation of a recycling endosome resident small GTPase… CONTINUE READING
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Recycling endosomes

SC van Ijzendoorn
J Cell Sci 119(Pt 9): • 2006
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