TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.

@article{Heer2007TLRSF,
  title={TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.},
  author={Alex Kaspar Heer and Abdijapar Shamshiev and Alena Donda and Satoshi Uematsu and Shizuo Akira and Manfred Kopf and Benjamin J Marsland},
  journal={Journal of immunology},
  year={2007},
  volume={178 4},
  pages={
          2182-91
        }
}
Influenza is a ssRNA virus that has been responsible for widespread morbidity and mortality; however, the innate immunological mechanisms that drive the adaptive anti-influenza immune response in vivo are yet to be fully elucidated. TLRs are pattern recognition receptors that bind evolutionarily conserved pathogen-associated molecular patterns, induce dendritic cell maturation, and consequently aid the development of effective immune responses. We have examined the role of TLRs in driving… CONTINUE READING
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