TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy.

@article{Reijmerink2010TLRrelatedPA,
  title={TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy.},
  author={Naomi E. Reijmerink and Renske W. B. Bottema and M Kerkhof and Jorrit Gerritsen and Foekje F. Stelma and Carel Thijs and Constant Paul van Schayck and Henriette A Smit and Bert A Brunekreef and Gerard H Koppelman and Dirkje S Postma},
  journal={Allergy},
  year={2010},
  volume={65 2},
  pages={199-207}
}
BACKGROUND The toll-like receptor (TLR)-related pathway is important in host defence and may be crucial in the development of asthma and atopy. Numerous studies have shown associations of TLR-related pathway genes with asthma and atopy phenotypes. So far it has not been investigated whether gene-gene interactions in this pathway contribute to atopy and asthma development. METHODS One hundred and sixty-nine haplotype tagging single nucleotide polymorphisms (SNPs) of 29 genes (i.e. membrane and… CONTINUE READING

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