TLR-mediated cell signaling by malaria GPIs.

  title={TLR-mediated cell signaling by malaria GPIs.},
  author={D Channe Gowda},
  journal={Trends in parasitology},
  volume={23 12},
Proinflammatory responses to malaria have crucial roles in controlling parasite growth and disease pathogenesis. The glycosylphosphatidylinositol (GPI) of Plasmodium falciparum is thought to be an important factor in the induction of proinflammatory responses. The GPI induces host cellular responses mainly through Toll-like receptor (TLR)2/MyD88-mediated signaling. Knowledge of the parasite-host factors involved in activating and regulating innate immune responses and of the associated… CONTINUE READING

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