TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM

@article{Couillault2004TLRindependentCO,
  title={TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM},
  author={Carole Couillault and Nathalie Pujol and J{\'e}r{\^o}me Reboul and Laurence Sabatier and Jean-François Guichou and Yuji Kohara and Jonathan J Ewbank},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={488-494}
}
Both plants and animals respond to infection by synthesizing compounds that directly inhibit or kill invading pathogens. We report here the identification of infection-inducible antimicrobial peptides in Caenorhabditis elegans. Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was controlled in part by tir-1, which encodes an ortholog of SARM, a Toll–interleukin 1 receptor (TIR) domain protein. Inactivation of tir-1 by RNA… CONTINUE READING
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