TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM

Abstract

Both plants and animals respond to infection by synthesizing compounds that directly inhibit or kill invading pathogens. We report here the identification of infection-inducible antimicrobial peptides in Caenorhabditis elegans. Expression of two of these peptides, NLP-29 and NLP-31, was differentially regulated by fungal and bacterial infection and was… (More)
DOI: 10.1038/ni1060

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@article{Couillault2004TLRindependentCO, title={TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM}, author={Carole Couillault and Nathalie Pujol and J{\'e}r{\^o}me Reboul and Laurence Sabatier and Jean-François Guichou and Yuji Kohara and Jonathan J Ewbank}, journal={Nature Immunology}, year={2004}, volume={5}, pages={488-494} }