TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease.

@article{Koller2008TLREO,
  title={TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease.},
  author={Barbara Koller and Matthias Kappler and Phillip Latzin and Amit Gaggar and Marcus Schreiner and Sherkin Takyar and Michael Kormann and Michael Kabesch and Dirk Roos and Matthias Griese and Dominik Hartl},
  journal={Journal of immunology},
  year={2008},
  volume={181 4},
  pages={
          2753-63
        }
}
Cystic fibrosis (CF) lung disease is characterized by infection with Pseudomonas aeruginosa and a sustained accumulation of neutrophils. In this study, we analyzed 1) the expression of MyD88-dependent TLRs on circulating and airway neutrophils in P. aeruginosa-infected CF patients, P. aeruginosa-infected non-CF bronchiectasis patients, and noninfected healthy control subjects and 2) studied the regulation of TLR expression and functionality on neutrophils in vitro. TLR2, TLR4, TLR5, and TLR9… CONTINUE READING

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