TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.

@article{Taylor2008TLRAR,
  title={TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection.},
  author={Patricia A. Taylor and Michael J. Ehrhardt and Christopher Lees and Angela Panoskaltsis-Mortari and Arthur M. Krieg and Arlene H Sharpe and William Joseph Murphy and Jonathan S. Serody and Hiroaki Hemmi and Shizuo Akira and Robert H. Levy and Bruce R Blazar},
  journal={Blood},
  year={2008},
  volume={112 8},
  pages={3508-16}
}
Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor 9 (TLR9) ligation of host antigen-presenting cells (APCs), dependent upon host IFNgamma but independent of host IL-12, IL-6, or natural killer (NK) cells. Imaging studies showed… CONTINUE READING