TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.

@article{Chow2005TLRAR,
  title={TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk.},
  author={Edward Kai-Hua Chow and Ryan M O'connell and Stephen H. Schilling and Xiaofan Wang and Xin-yuan Fu and Genhong Cheng},
  journal={The EMBO journal},
  year={2005},
  volume={24 23},
  pages={4071-81}
}
Transforming growth factor-beta (TGF-beta) and type I interferon (IFN) autocrine/paracrine loops are recognized as key mediators of signaling cascades that control a variety of cellular functions. Here, we describe a novel mechanism by which Toll-like receptor (TLR) agonists utilize these two autocrine/paracrine loops to differentially regulate the… CONTINUE READING