TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus

@article{Abt2016TLR7AE,
  title={TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus},
  author={Michael Abt and Charlie G. Buffie and Bo{\vz}e Su{\vs}ac and Simone Becattini and Rebecca A Carter and Ingrid M. Leiner and James W. Keith and David Artis and Lisa Colleen Osborne and Eric G. Pamer},
  journal={Science Translational Medicine},
  year={2016},
  volume={8},
  pages={327ra25-327ra25}
}
Antibiotic administration can disrupt the intestinal microbiota and down-regulate innate immune defenses, compromising colonization resistance against orally acquired bacterial pathogens. Vancomycin-resistant Enterococcus faecium (VRE), a major cause of antibiotic-resistant infections in hospitalized patients, thrives in the intestine when colonization resistance is compromised, achieving extremely high densities that can lead to bloodstream invasion and sepsis. Viral infections, by mechanisms… CONTINUE READING
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