TLR-4 and CD14 Polymorphisms in Respiratory Syncytial Virus Associated Disease

TLR-4 and CD14 Polymorphisms in Respiratory Syncytial Virus Associated Disease},
  author={Beena Puthothu and Johannes Forster and Andrea Heinzmann and Marcus Krueger},
  booktitle={Disease markers},
Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested whether an association exists between severe RSV associated diseases and polymorphisms within TLR4 and CD14. We genotyped the CD14 promotor polymorphism -C159T and the two common… CONTINUE READING
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