TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo.

@article{ivkovi2011TLR2A,
  title={TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo.},
  author={Ana Živkovi{\'c} and Omar Ibraheem Sharif and Karin Stich and Bianca Doninger and Mario Biaggio and Jacques Colinge and Martin H Bilban and Ildiko Mesteri and Parastoo Hazemi and Rosa Lemmens-Gruber and Sylvia Knapp},
  journal={Journal of immunology},
  year={2011},
  volume={186 3},
  pages={1608-17}
}
The pore-forming toxin Panton-Valentine leukocidin (PVL) is carried by community-acquired methicillin-resistant Staphylococcus aureus and associated with necrotizing pneumonia together with poor prognosis of infected patients. Although the cell-death-inducing properties of PVL have previously been examined, the pulmonary immune response to PVL is largely unknown. Using an unbiased transcriptional profiling approach, we show that PVL induces only 29 genes in mouse alveolar macrophages, which are… CONTINUE READING

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