TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers

Abstract

BACKGROUND Chronic pain patients have increased peripheral blood mononuclear cell Interkeukin-1β production following TLR2 and TLR4 simulation. Here we have used a human-to-rat and rat-to-human approach to further investigate whether peripheral blood immune responses to TLR agonists might be suitable for development as possible systems biomarkers of chronic… (More)
DOI: 10.1371/journal.pone.0077799

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Cite this paper

@inproceedings{Kwok2013TLR2A, title={TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers}, author={Yuen Hei Kwok and Jonathan Tuke and Lauren L. Nicotra and Peter M Grace and Paul Edward Rolan and Mark R Hutchinson}, booktitle={PloS one}, year={2013} }