TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement

@article{Soylu2009TLR2AT,
  title={TLR-2 Arg753Gln, TLR-4 Asp299Gly, and TLR-4 Thr399Ile polymorphisms in Henoch Schonlein purpura with and without renal involvement},
  author={Alper Soylu and Sefa Kızıldağ and Salih Kavukçu and Sultan Cing{\"o}z and Mehmet T{\"u}rkmen and Belde Kasap Demir and Meral Sakızlı},
  journal={Rheumatology International},
  year={2009},
  volume={30},
  pages={667-670}
}
Infections may trigger or aggravate glomerulonephritidis and renal vasculitis like Henoch Schonlein purpura (HSP). HSP is seen more frequently in patients with familial Mediterranean fever in which TLR-2 Arg753Gln polymorphism frequency is increased. Although renal involvement is the most important factor affecting the prognosis in HSP, it is not known which patients will have renal disease or why some patients have severe renal involvement while some others have mild renal disease. We… CONTINUE READING

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