TLR–Dependent Control of Francisella tularensis Infection and Host Inflammatory Responses

@inproceedings{Abplanalp2009TLRDependentCO,
  title={TLR–Dependent Control of Francisella tularensis Infection and Host Inflammatory Responses},
  author={Allison L. Abplanalp and Ian R. Morris and Bijaya Kumar Parida and Judy M. Teale and Michael T. Berton},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Francisella tularensis is the causative agent of tularemia and is classified as a Category A select agent. Recent studies have implicated TLR2 as a critical element in the host protective response to F. tularensis infection, but questions remain about whether TLR2 signaling dominates the response in all circumstances and with all species of Francisella and whether F. tularensis PAMPs are predominantly recognized by TLR2/TLR1 or TLR2/TLR6. To address these questions, we have explored… CONTINUE READING