TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity.

@article{Bartolomucci2006TLQP21AV,
  title={TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity.},
  author={Alessandro Bartolomucci and Giorgio La Corte and Roberta Possenti and Vittorio Locatelli and Antonello Emilio Rigamonti and Antonio Torsello and Elena Bresciani and Ilaria Bulgarelli and Roberto Rizzi and Flaminia Pavone and Francesca R D'Amato and Carlo Severini and Giuseppina Mignogna and Anthony Giorgi and Maria Eugenia Schinin{\'a} and Gianfranco Elia and Carla Brancia and G-L Ferri and Roberto Conti and Barbara Ciani and Tiziana Pascucci and Giacomo Dell'Omo and Eugenio E. M{\"u}ller and Andrea C. Levi and Alistair Moles},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 39},
  pages={
          14584-9
        }
}
The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely characterized panel of neuropeptides. Until now, it was an unproved assumption that VGF-derived peptides could regulate metabolism. Here, a VGF peptide designated TLQP-21 was identified in rat brain extracts by means of immunoprecipitation, microcapillary liquid chromatography-tandem MS, and database searching algorithms. Chronic… CONTINUE READING
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