TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family

@article{Nakayama1997TLP1AG,
  title={TLP1: A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family},
  author={Jun-ichi Nakayama and Motoki Saito and Hideo Nakamura and Akira Matsuura and Fuyuki Ishikawa},
  journal={Cell},
  year={1997},
  volume={88},
  pages={875-884}
}
We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240 and p230 were copurified with telomerase activity in a series of extensive purification experiments. These results strongly suggest that the TLP1 proteins are components of, or… CONTINUE READING