TLC1: template RNA component of Saccharomyces cerevisiae telomerase.

@article{Singer1994TLC1TR,
  title={TLC1: template RNA component of Saccharomyces cerevisiae telomerase.},
  author={Miriam S. Singer and Daniel E Gottschling},
  journal={Science},
  year={1994},
  volume={266 5184},
  pages={
          404-9
        }
}
Telomeres, the natural ends of linear eukaryotic chromosomes, are essential for chromosome stability. Because of the nature of DNA replication, telomeres require a specialized mechanism to ensure their complete duplication. Telomeres are also capable of silencing the transcription of genes that are located near them. In order to identify genes in the budding yeast Saccharomyces cerevisiae that are important for telomere function, a screen was conducted for genes that, when expressed in high… CONTINUE READING
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