• DOI:10.1371/journal.pone.0090224
Corpus ID: 14751412

TL-118 and Gemcitabine Drug Combination Display Therapeutic Efficacy in a MYCN Amplified Orthotopic Neuroblastoma Murine Model – Evaluation by MRI

@article{KomarStossel2014TL118AG,
  title={TL-118 and Gemcitabine Drug Combination Display Therapeutic Efficacy in a MYCN Amplified Orthotopic Neuroblastoma Murine Model – Evaluation by MRI},
  author={Chani Komar-Stossel and E. Gross and E. Dery and N. Corchia and K. Meir and I. Fried and R. Abramovitch},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}

Chani Komar-Stossel, E. Gross, +4 authors R. Abramovitch

Published 2014

Medicine

PLoS ONE

Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor with up to 50% of NB patients classified as having high-risk disease with poor long-term survival rates. The poor clinical outcome and aggressiveness of high-risk NB strongly correlates with enhanced angiogenesis, suggesting anti-angiogenic agents as attractive additions to the currently insufficient therapeutics. TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis. In the current… CONTINUE READING

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