TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization.

Abstract

PURPOSE This study aims to investigate the role of the aberrant expression of Transkelolase-like 1 (TKTL1) in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and to characterize TKTL1 contribution to HNSCC tumorigenesis through aerobic glycolysis and HIF1alpha stabilization. EXPERIMENTAL DESIGN TKTL1 promoter hypomethylation and mRNA/protein… (More)
DOI: 10.1158/1078-0432.CCR-09-2604

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