TITLE : P olymorphisms in Toll-like Receptor 4 are not associated with asthma or atopy-related phenotypes

@inproceedings{Raby2002TITLEP,
  title={TITLE : P olymorphisms in Toll-like Receptor 4 are not associated with asthma or atopy-related phenotypes},
  author={Benjamin A. Raby and Walter T. Klimecki and Catherine Laprise and Yannick Renaud and Janet M Faith and Mathieu Lemire and Celia Greenwood and Katherine M. Weiland and Christoph Lange and Lyle John Palmer and Ross Lazarus and Donata Vercelli and D. J. Kwiatkowski and Edwin K. Silverman and Fernando D. Martinez and Thomas J. Hudson and Scott T. Weiss},
  year={2002}
}
Toll-like receptor 4 (TLR4) is the principal receptor for bacterial endotoxin recognition, and functional variants in the gene confer endotoxin-hyporesponsiveness in humans. Furthermore, there is evidence that endotoxin exposure during early life is protective against the development of atopy and asthma, although this relationship remains poorly understood. It is therefore possible that genetic variation in the TLR4 locus contributes to asthma susceptibility. In this study we characterize the… CONTINUE READING