TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

@inproceedings{Sakaguchi2011TIRAPAA,
  title={TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding},
  author={Masakiyo Sakaguchi and Hitoshi Murata and Ken-ichi Yamamoto and Tomoyuki Ono and Yoshihiko M. Sakaguchi and Akira Motoyama and Toshihiko Hibino and Ken Kataoka and Nam-ho Huh},
  booktitle={PloS one},
  year={2011}
}
The receptor for advanced glycation end products (RAGE) is thought to be involved in the pathogenesis of a broad range of inflammatory, degenerative and hyperproliferative diseases. It binds to diverse ligands and activates multiple intracellular signaling pathways. Despite these pivotal functions, molecular events just downstream of ligand-activated RAGE have been surprisingly unknown. Here we show that the cytoplasmic domain of RAGE is phosphorylated at Ser391 by PKCζ upon binding of ligands… CONTINUE READING

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