TIR-containing adaptors in Toll-like receptor signalling.

@article{Jenkins2010TIRcontainingAI,
  title={TIR-containing adaptors in Toll-like receptor signalling.},
  author={Kristie A. Jenkins and Ashley Mansell},
  journal={Cytokine},
  year={2010},
  volume={49 3},
  pages={
          237-44
        }
}
  • Kristie A. Jenkins, Ashley Mansell
  • Published in Cytokine 2010
  • Biology, Medicine
  • While the Toll-like receptors (TLRs) are responsible for the recognition and response to pathogen ligands, increasing evidence suggests that the family of five cytosolic Toll/IL-1 receptor (TIR) adaptor proteins also play a crucial role in the specificity of the response. Genetic studies in mice, and increasingly in human polymorphic populations, have given us a greater understanding the role these adaptors play in orchestrating and coordinating the multifaceted immune response to multiple… CONTINUE READING

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