TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response

@inproceedings{Rosales2015TIPRLIP,
  title={TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response},
  author={Kimberly Romero Rosales and Michael Austin Ross Reid and Ying Yang and Thai Quang Tran and Wen-I Wang and Xazmin Helen Lowman and Michael Pan and Mei Kong and Michael Shing-Yan Huen},
  booktitle={PloS one},
  year={2015}
}
Despite advances in our understanding of protein kinase regulation in the DNA damage response, the mechanism that controls protein phosphatase activity in this pathway is unclear. Unlike kinases, the activity and specificity of serine/threonine phosphatases is governed largely by their associated proteins. Here we show that Tip41-like protein (TIPRL), an evolutionarily conserved binding protein for PP2A-family phosphatases, is a negative regulator of protein phosphatase 4 (PP4). Knockdown of… CONTINUE READING

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