TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response

@article{Rosales2015TIPRLIP,
  title={TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response},
  author={K. Rosales and Michael A. Reid and Y. Yang and Thai Q. Tran and W. Wang and X. Lowman and Min Pan and M. Kong},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
  • K. Rosales, Michael A. Reid, +5 authors M. Kong
  • Published 2015
  • Biology, Medicine
  • PLoS ONE
  • Despite advances in our understanding of protein kinase regulation in the DNA damage response, the mechanism that controls protein phosphatase activity in this pathway is unclear. Unlike kinases, the activity and specificity of serine/threonine phosphatases is governed largely by their associated proteins. Here we show that Tip41-like protein (TIPRL), an evolutionarily conserved binding protein for PP2A-family phosphatases, is a negative regulator of protein phosphatase 4 (PP4). Knockdown of… CONTINUE READING
    8 Citations
    Methylation-regulated decommissioning of multimeric PP2A complexes
    • 14
    • Highly Influenced
    • PDF
    Functional roles of protein phosphatase 4 in multiple aspects of cellular physiology: a friend and a foe
    • 5
    • PDF
    Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion
    • 9
    IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
    • 26
    • PDF
    PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer’s Disease Brain
    • 2
    • PDF

    References

    SHOWING 1-10 OF 17 REFERENCES
    Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates γ-H2AX
    • 135
    • PDF
    Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant γ-H2AX and Suppresses DNA Double Strand Break Repair*
    • 92
    • PDF
    A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
    • 196
    • Highly Influential
    • PDF
    A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
    • 462
    • PDF
    Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, α4 and the mammalian ortholog of yeast Tip41 (TIPRL)
    • 33
    • Highly Influential
    A Novel, Evolutionarily Conserved Protein Phosphatase Complex Involved in Cisplatin Sensitivity*S
    • 175
    • Highly Influential
    • PDF
    Alpha4 is an essential regulator of PP2A phosphatase activity.
    • 131