TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage.

@article{Cho2001TIP49bAR,
  title={TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage.},
  author={Sung Gyu Cho and Anindita Bhoumik and Limor Broday and Vladimir N. Ivanov and B Rosenstein and Ze'ev A Ronai},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 24},
  pages={8398-413}
}
Activating transcription factor 2 (ATF2/CRE-BP1) is implicated in transcriptional control of stress-responsive genes. A yeast two-hybrid screen identified TBP-interacting protein 49b (TIP49b), a component of the INO80 chromatin-remodeling complex, as a novel ATF2-interacting protein. TIP49b's association with ATF2 is phosphorylation dependent and requires amino acids 150 to 248 of ATF2 (ATF2(150-248)), which are implicated in intramolecular inhibition of ATF2 transcriptional activities. Forced… CONTINUE READING