TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.

@article{Ding2003TIP49RB,
  title={TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.},
  author={Weifeng Ding and Nana Lee and Eric R. Fearon},
  journal={Cancer research},
  year={2003},
  volume={63 24},
  pages={8726-34}
}
Beta-catenin has a key role in Wnt signaling via effects on T-cell factor (TCF)-mediated transcription. Mutational defects in beta-catenin regulation are seen in many cancers, leading to elevated beta-catenin levels, enhanced binding of beta-catenin to TCFs, and increased expression of TCF-regulated genes. Factors cooperating with beta-catenin in transcription of TCF-regulated genes are not well defined. TIP49, an ATPase previously implicated as a cofactor for oncogenic transformation by c-Myc… CONTINUE READING

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