TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice

@inproceedings{Li2013TIP30LE,
  title={TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice},
  author={Ai-min Li and Chengliang Zhang and Shenglan Gao and Fengsheng Chen and Chengfen Yang and Rong-cheng Luo and Hua Xiao},
  booktitle={Oncogene},
  year={2013}
}
Lung adenocarcinoma, the most common type of human non-small cell lung cancer (NSCLC), frequently overexpresses epidermal growth factor receptor (EGFR). However, the mechanisms underlying EGFR overexpression are not completely understood. Recent studies have identified that decreased expression of TIP30 (30kDa HIV-1 Tat interacting protein) is associated with the metastasis of human NSCLCs, but a causative relationship between TIP30 deficiency and NSCLC development remains unclear. We show here… CONTINUE READING
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