TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production

@inproceedings{Han2018TIMP3OI,
  title={TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production},
  author={Xiu-guo Han and Hui-min Mo and Xu-qiang Liu and Yan Li and Lin Du and Han Qiao and Qiming Fan and Jie Zhao and Shu-hong Zhang and Tingting Tang},
  booktitle={Front. Genet.},
  year={2018}
}
Osteosarcoma is the most common bone cancer in children and adolescents. Tissue inhibitors of metalloproteinases (TIMPs)-3 inhibit matrix metalloproteinases to limit extracellular matrix degradation. Cisplatin is a widely used chemotherapeutic drug used to cure osteosarcoma. Interleukin (IL)-6 and TIMP3 play important roles in the drug resistance of osteosarcoma; however, their relationship in this process remains unclear. This study aimed to explore the role of TIMP3 in the cisplatin… CONTINUE READING