TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118

@article{Oh2006TIMP2UR,
  title={TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118},
  author={Junseo Oh and Tere Diaz and Beiyang Wei and Han Chao Chang and Makoto Noda and William G Stetler-Stevenson},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4230-4234}
}
We previously demonstrated that TIMP-2 increases the association of Crk with C3G and via subsequent activation of Rap1 enhances the expression of RECK, a membrane-anchored MMP inhibitor. In the present study, we investigate the mechanism of how the TIMP-2 signal is transduced from the α3β1 integrin receptor to the Crk-C3G-Rap1 molecular complex. TIMP-2 treatment of human microvascular endothelial cells (hMVECs) increased the phosphorylation levels of Src at Tyr-527, the negative regulatory site… CONTINUE READING