TIMP-2 Mediated Inhibition of Angiogenesis An MMP-Independent Mechanism

  title={TIMP-2 Mediated Inhibition of Angiogenesis An MMP-Independent Mechanism},
  author={Dong-Wan Seo and Hongmei Li and Liliana Gu{\'e}dez and Paul T Wingfield and Tere Diaz and Rita G Salloum and Bei-yang Wei and William G Stetler-Stevenson},
Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP) activity critical for extracellular matrix turnover associated with both physiologic and pathologic tissue remodeling. We demonstrate here that TIMP-2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. These effects require alpha 3 beta 1 integrin-mediated binding of TIMP-2 to endothelial cells. Further, TIMP-2 induces a… CONTINUE READING
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