TIMP-1 promotes VEGF-induced neovascularization in the retina.

  title={TIMP-1 promotes VEGF-induced neovascularization in the retina.},
  author={Eri Yamada and Takao Tobe and Hiroyuki Yamada and Namiko Okamoto and Debra Jeske Zack and Zena Werb and Paul D. Soloway and Peter Anthony Campochiaro},
  journal={Histology and histopathology},
  volume={16 1},
Proteolysis of vascular basement membranes and surrounding extracellular matrix is a critical early step in neovascularization. It requires alteration of the balance between matrix metalloproteinases (MMPs) and proteins that bind to and inactivate MMPs, tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 has been demonstrated to inhibit neovascularization in chick chorioallantoic membranes. However, TIMP-1 has also been shown to either promote or inhibit cell proliferation and migration in… CONTINUE READING
24 Citations
47 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 24 extracted citations


Publications referenced by this paper.
Showing 1-10 of 47 references

lncreased vascular endothelial growth factor ( VEGF ) and transforming growth factor - beta ( TGF - beta ) in experimental autoimmune uveoretinitis : upregulation of VEGF without neovascularization

  • A. VinoresS., Chan C.-C., +5 authors A. CampochiaroP.
  • J . Neuroimmunol .
  • 1998

Matrix metalloproteinase - 2 and tissue inhibitor of metalloproteinase - 1 in the retinal pigment epithelium and interphotoreceptor matrix : vectorial secretion and regulation

  • C. PadgettL., Lui G.-M., Z. Werb, M. LaVailM.
  • Exp . Eye Res .
  • 1997

Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4

  • J. Greene, S. WangM., E. LiuY.L., A. RaymondL., C. Rosen, E. ShiY.N.
  • J . Biol . Chem
  • 1996

Similar Papers

Loading similar papers…