TIMP-1 is significantly associated with objective response and survival in metastatic colorectal cancer patients receiving combination of irinotecan, 5-fluorouracil, and folinic acid.

@article{Srensen2007TIMP1IS,
  title={TIMP-1 is significantly associated with objective response and survival in metastatic colorectal cancer patients receiving combination of irinotecan, 5-fluorouracil, and folinic acid.},
  author={Nanna M{\o}ller S{\o}rensen and Per Bystr{\"o}m and Ib Jarle Christensen and {\AA}ke Berglund and Hans J{\o}rgen Nielsen and Nils Age Br{\"u}nner and Bengt Glimelius},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 14},
  pages={
          4117-22
        }
}
PURPOSE Tissue inhibitor of metalloproteinase-1 (TIMP-1) is known to protect cells against apoptosis. We raised the hypothesis that elevated tumor tissue levels and thereby plasma levels of TIMP-1 would predict resistance to apoptosis-inducing chemotherapy. EXPERIMENTAL DESIGN Ninety patients with metastatic colorectal cancer were included in the study. Plasma TIMP-1 and serum carcinoembryonic antigen (CEA) were measured in samples obtained before the first cycle of chemotherapy. RESULTS… CONTINUE READING

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