TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure.

@article{Yamamoto2006TIMP1MMP9II,
  title={TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure.},
  author={Satoshi Yamamoto and Justin H H Nguyen},
  journal={The Journal of surgical research},
  year={2006},
  volume={134 2},
  pages={307-14}
}
BACKGROUND Fulminant hepatic failure (FHF) is a devastating disease. When coma sets in, brain edema develops, changing FHF into a lethal condition. Liver transplantation is the definitive treatment. However, a third of these patients die as the result of brain edema before a donor becomes available. Tissue inhibitor of matrix metalloproteinase (MMP), or TIMP, and MMP-9 are implicated in ischemic brain edema. We thus hypothesized that an imbalance in TIMP-1/MMP-9 relationship plays a role in the… CONTINUE READING