TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock.

  title={TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock.},
  author={Vipin Suri and Anne E. Lanjuin and Michael Rosbash},
  journal={The EMBO journal},
  volume={18 3},
The timeless protein (TIM) is a central component of the circadian pacemaker machinery of the fruitfly Drosophila melanogaster. Both TIM and its partner protein, the period protein PER, show robust circadian oscillations in mRNA and protein levels. Yet the role of TIM in the rhythm generation mechanism is largely unknown. To analyze TIM function, we constructed transgenic flies that carry a heat shock-inducible copy of the timeless gene (tim) in an arrhythmic tim loss-of-function genetic… CONTINUE READING
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Circadian oscillations and autoregulation of timeless RNA

  • A. Sehgal, A. Rothenfluh-Hilfiker, M. Hunter-Ensor, Y. Chen, M. Myers, M. W. Young
  • Science
  • 1995
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