TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

@inproceedings{Sakuishi2013TIM3FOXP3RT,
  title={TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer},
  author={Kaori Sakuishi and Shin Foong Ngiow and Jenna M Sullivan and Michele W. L. Teng and Vijay K Kuchroo and Mark J Smyth and Ana Carrizossa Anderson},
  booktitle={Oncoimmunology},
  year={2013}
}
T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as cancer. In addition to exhausted CD8+ T cells, highly suppressive regulatory T cells (Tregs) represent a significant barrier against the induction of antitumor immunity. We have found that the majority of intratumoral FOXP3+ Tregs express TIM3. TIM3+ Tregs co-express PD-1, are highly suppressive and comprise a… CONTINUE READING