TIM-family proteins inhibit HIV-1 release.

  title={TIM-family proteins inhibit HIV-1 release.},
  author={Minghua Li and Sherimay D. Ablan and Chunhui Miao and Yi-Min Zheng and Matthew S. Fuller and Paul D. Rennert and Wendy J. Maury and Marc C. Johnson and Eric O. Freed and Shan-Lu Liu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 35},
Accumulating evidence indicates that T-cell immunoglobulin (Ig) and mucin domain (TIM) proteins play critical roles in viral infections. Herein, we report that the TIM-family proteins strongly inhibit HIV-1 release, resulting in diminished viral production and replication. Expression of TIM-1 causes HIV-1 Gag and mature viral particles to accumulate on the plasma membrane. Mutation of the phosphatidylserine (PS) binding sites of TIM-1 abolishes its ability to block HIV-1 release. TIM-1, but to… CONTINUE READING
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